In addition to its protective physiological roles, it is now clear that inflammation plays a key role in the etiology of many diseases including cancer, atherosclerosis, and asthma. Inflammation involves multiple pathways, enzymes and mediators. Among the many biomarkers for the quantification of inflammatory responses, histamine production and eicosanoids metabolism have proven particularly useful.

Histamine is stored in basophils and mast cells and is a key mediator of inflammation.  It binds to three distinct receptors causing bronchoconstriction, vasodilation and increased vascular permeability.  Although histamine has been analyzed by other methods, an attractive feature of this ELISA is that whole blood can be treated with stimulants and the histamine produced can be measured in the same reaction volume (prodotti correlati).

Cortisol is the most potent glucocorticoid produced and secreted by the adrenal cortex.  It has multiple physiological and pharmacological actions, including anti-inflammatory effects (prodotti correlati).
 
13, 14-Dihydro-Prostaglandin F2α is derived from PGF2α through the consecutive actions of 15-hydroxy prostaglandin dehydrogenase and prostaglandin 13 reductase.  Analysis of this specific prostaglandin metabolite in urine has been extensively documented and widely used as a reliable index of the activation of the cyclooxygenase pathway during inflammation (prodotti correlati).